Serratiopeptidase Serrapeptase

Serratiopeptidase (Serrapeptase) : Uses, Dosage and Side Effects.

Serratiopeptidase (Serrapeptase ) is proteolytic enzyme (protease) which is involved in the breaking down of proteins. This enzyme increases the rate of proteolysis  which means the breakdown of proteins into smaller polypeptides or single amino acids.

Also known as serralysin, serrapeptase, serratiapeptase, serratia peptidase, serratio peptidase.

These enzymes are found in the intestines of the silkworm and allow the emerging moth to dissolve its cocoon.

Serratiopeptidase was initially used During the 1950s in the USA and in Japan for therapeutic purposes in 1960.Research conducted in Japan and Europe during the 1980s and 1990s showed that serratiopeptidase was the most effective anti-inflammatory agent compared to other enzyme preparation. Since then it is in use for over 40 yrs in Europe and Japan for the treatment of pain and inflammation associated with various conditions.


Serratiopeptidase (Serrapeptase) has been used for its anti-inflammatory properties for many years. Now it is marketed as a joint health supplement.

Serratiopeptidase (Serrapeptase) : Benefits & Uses

Researchers in Europe and Japan proposed several benefits of Serratiopeptidase in the last many years and it has been found to have several possible uses and promising health benefits.

  • Reduce Inflammation-Serrapeptase also decreases inflammation, possibly because it thins fluids so they can drain from inflamed areas more easily and prevents excessive protein build-up.
  • Curb Pain-Serrapeptase may offer pain relief for people with certain inflammatory ear, nose, and throat conditions. It may also be beneficial for minor postoperative dental surgeries.
  • Prevent Infections– Even though they kill your helpful gut bacteria, sometimes antibiotics really are the best course of action. Serrapeptase benefits you by making antibiotics more effective.
  • Dissolve Blood Clots-This could enable serrapeptase to dissolve plaque in your arteries or dissolve blood clots that may lead to stroke or heart attack.
  • Respiratory Diseases Use-Serrapeptase may increase the clearance of mucus and reduce inflammation in the lungs in people with chronic respiratory diseases (CRD).
  • Facial Swelling After Sinus Surgery-Serrapeptase may reduce facial swelling after some types of sinus surgery but evidence is lacking to support the use of serrapeptase for reducing swelling after dental surgery or soft tissue injuries.
  • Breast Engorgement-It reduced breast pain, swelling, and hardness in 60 out of 70 patients in one study. Further clinical trials are needed to rate its safety and effectiveness.(1) 
  • Inflammatory Venous Disease-Twenty patients received seaprose S and 20 serratio-peptidase. The findings indicate that seaprose S was more effective and better tolerated than serratio-peptidase.(2) 
  • Dental Implant Inflammation-Patients that received serrapeptase healed faster and had lower implant failure rates than patients receiving placebo or NSAIDs.(3) 

    The existing scientific evidence for Serratiopeptidase is insufficient to support its use as an analgesic and health supplement. (4)

Serratiopeptidase (Serrapeptase) :Dosage

Serrapetase dosage of 30 mg /day was used in most of the clinical trials which were divided into 3 parts. The dosage range from 10 mg /day to 60 mg /day. There are some recommendations which also suggest the dosage for 15 mg per day t0 30 mg per day.

Some health expert-recommended dose for serrapeptase is 10-60 mg per day and should be supplemented on an empty stomach, which is 30 minutes before a meal or two hours after a meal, three times a day. Most studies use 10mg of serrapeptase taken every eight hours.

If taken orally serrapeptase is destroyed due to acid in our stomach and hence it becomes ineffective before it reach the intestine. To prevent serrapeptase from being destroyed by stomach acid these capsules are enteric-coated. Choose an enteric-coated tablet that dissolves lower down in the intestinal tract

Serrapeptase is measured in units, with 10 mg equalling 20,000 units of enzyme activity.

Stop using Serratiopeptidase at least 2 weeks before a scheduled surgery as it may interfere with blood clotting. Inform your doctor if you have liver or kidney disease or problems with your blood clotting mechanism.

You should never follow the recommended doses on the product label or advice by the health expert.

Serratiopeptidase (Serrapeptase) :Side Effect

Serrapeptase is considered to be safe for adults when taken by mouth in a short-term period of up to 4 weeks. The long-term safety of serrapeptase is not known.
There are several reports which claims and highlight the side effect.

  • Bleeding disorders: Serrapeptase might interfere with blood clotting, so some researchers worry that it might make bleeding disorders worse.
  • Surgery: Serrapeptase might interfere with blood clotting. There is a concern that it might increase bleeding during and after surgery. 
  • Skin reactions:
  • Muscle and joint pain
  • Poor appetite
  • Nausea
  • Stomach pain
  • Cough